ＣＹＢＥＲＤＹＮＥ（7779） – [Delayed]Financial Result Briefing for the Fiscal Year Ended March 31, 2022

Consolidated Financial Result Briefing for the Fiscal Year Ended March 31, 2022CYBERDYNE Inc.May 13, 2022Table of contents123456CYBERDYNE, Inc.2Consolidated Financial StatementOutline of the business【Medical】Cybernics Treatment【Healthcare】Neuro HALFITStrategy for growthSDGs for Society5.0/5.1Consolidated Financial StatementCYBERDYNE, Inc.3Consolidated financial results – year-on-year comparison for the fiscal year ended March 31, 2022Revenue : 2,150M（+14.7% YOY）Operating profit: -868M（Increase of SG&A）Profit: -492M (decrease of finance income)(Unit: Millions of Yen)Revenue（year on year）- Rental +184M (Medical HAL overseas, sleep app)- Sales -164M (One time sales in the previous FY)- Service +255M (recovery of Robocare, acquired a base 
FY2020(Apr.1-Mar.31)FY2021(Apr.1-Mar.31)+/-+/-% in the U.S.)Revenue(Gross profit)1,875(1,283)2,150(1,462)+276(+179)+14.7％(+13.9%)SG&A (+316M) (year on year)Operating profit-700-868-168 – SG&A of acquired company +213M – M&A related expenses　　　 +102M　Profit before tax408-379-787 Decrease of finance income (-372M) (year on year) Gain related to CEJ Fund (-244M) (year on year)Profit attributable to owners of the parent-59-492-433CYBERDYNE, Inc.4ーーーConsolidated financial results – the quarterly resultfor the fiscal year ended March 31, 2022【Consolidated statement of profit or loss for the consolidated fiscal year ended March 31, 2022】YoY +27.9%
QoQ +54.1%(Unit: Millions of Yen)FY2020Q1-Q4
(Apr.1-Mar.31)FY2021Year on yearQ1(Apr.1-Jun.30)Q2(Jul.1-Sep.30)Q3(Oct.1-Dec.31)Q4(Jan.1-Mar.31)Q1-Q4
(Apr.1-Mar.31)+/-+/-%380（+5.9%)445(+2.3%)521(+15.2%)803(+27.9%)2,150(+14.7%)+276+14.7%Revenue　(year on year) Cost of salesGross profit R&D expenses Other SG&A Other income/expenseOperating profit Finance income/expense　OtherProfit before taxProfit attributable to owner of the parentCYBERDYNE, Inc.1,8755911,2836891,471176-700768341408-5910327718839119-283413-265-27610334216238912-1972153-123-15115636517339734-17038-160-159326478190610103-21836622169956881,4627131,787169-86839496-379-492+97+179+23+316-7-168-375-245-787-433+16.4%+13.9%+3.4%+21.5%-3.8%-48.6%-68.3%ーーーProperty tax 92M*Lump sum payment in Q4Gain from valuation difference of investment securities 368M5Consolidated financial results by type of transaction and prospectDoubled personal services sales drives the growth of companies sales(Unit: Millions of yen)2,150+195%
year on year1,875Service＋255MSales -164MRental+184•Acquisition of basis in U.S. to develop medical services • Recovery of Robocare in Japan and German Treatment Center• One time sales in the previous FY
(Disinfection/cleaning robot)• Expansion of HAL rental to overseas• Medical HAL Lower Limb for APAC and EU• HAL Lumbar for Well-being for England• Service fee from sleeping appService: Revenue from service at a point of timeSales: Revenue from sales at a point of timeRental and maintenance: 
revenue over timeCYBERDYNE, Inc.FY2020FY202165242681693331,4571,273Revenue from rental and maintenance (by products)Increase of rental revenue from Medical HAL Lower Limb Type etc.ProductFY2020FY2021For hospitals
(to improve patient’s physical function)HAL Lower Limb Type
(medical)HAL Lower Limb Type
(non-medical)HAL Single Joint TypeFor Well-beingHAL Lumbar TypeFor Labor SupportHAL Lumbar TypeAutonomous navigation robot 
(disinfection/cleaning, transportation etc.)OtherTotalCYBERDYNE, Inc.49119612724512961241,2731,457(millions of yen)(Composition%)Increase of rental towards South East Asia and Europe564188132251985117439%13%9%17%7%4%12%100%Large scale orders towards Hampshire, England (Q3)Service fee from a sleeping app (Q2)7Consolidated financial results -year on year comparisonby geographical regionsRatio of sales outside Japan increases to 30%YOY EMEA (Mainly EU) x1.8 Americas (mainly U.S.) x15.3Americas 1%¥16 MillionEMEA 6%¥109 Million※APAC 11%¥200 MillionAmericas 11%¥245 MillionEMEA 9%¥191 MillionAPAC 10%¥219 MillionJapan83% (¥1,550 Million)FY2020CYBERDYNE, Inc.Americas: North, Central and South AmericaEMEA : Europe, the Middle East and AfricaAPAC : Asia-Pacific *Revenue from Japan is stated separatelyJapan70%(¥1,496 Million)FY20218Ref) by geographical regions and type of transaction【Accumulated result for Fiscal Year Ended March 2022】*brackets represent the numbers from the previous year)(Unit: Millions of yen)Increase from medical service fee in the U.S. (from Q4)FY2021（FY2020）JapanAmericasEMEAAPACTotalRental1,124(1,052)20(16)111(65)202(140)1,457(1,273)Sales145(280)0(-)9(-)15(53)169(333)Service227(218)225(-)71(44)1(6)524(268)Total1,496(1,550)245(16)191(109)219(200)2,150(1,875)HAL Lumbar Type: Hampshire EnglandCYBERDYNE, Inc.Installation of HAL to Malaysia, India, Indonesia9Future sales growth targets (sales composition by transaction)Accelerate social implementation as an in-house service business3,500(Target)50%5,000(Target)50%Aggresive expansion• Personal healthcare services outside Japan• Personal healthcare services 
in Japan（Utilize M&A）Reinforcement• Rental to medical facilities 
overseas (APAC・EU)• Rental to medical facilities in Japan1,87514%2,15024%86%76%39%61%Services (Flow/BtoC)Rental etc.(Stock/BtoB)*Product sales are included in rentals, etc.CYBERDYNE, Inc.FY2020ActualFY2021ActualFY2022TargetFY2023Target102,5001,5005242682,5002,0001,6261,607Future sales growth targets (sales composition by geography)Strengthen and accelerate overseas business, especially in the U.S.5,000 (Target)3,500 (Target)54%46%Aggresive expansion• Treatment services in the US• Rental of HAL in EU and Asia
 (Utilize M&A)54%46%Reinforcement• Rental of HAL to hospital• Rental of HAL to individuals1,87517%2,15030%83%70%International revenueDomestic revenueCYBERDYNE, Inc.FY2020ActualFY2021ActualFY2022TargetFY2023Target112,7001,6006543252,3001,9001,4961,550Outline of the businessCYBERDYNE, Inc.12Realization of Techno-peer Support Society, Where human and technology lives together and supports each otherPromote innovation that “leaves no one behind”Maintain and manage their health even in old age and exercise their long-cultivated abilities to the fullest even if they have a disability due to a decline in physical functions caused by disease, accident, or aging, they can live with a higher degree of independence.BrainTechnologyBrainTechnology asthe new partnerSociety 5.0/5.1PeerSociety1.0Society2.0Society3.0Society4.0Promote healthy lives of many people with technology・・・aging, burdening-carePhysical spaceCyber spaceCybernics Space→ Create “Cybernics Industry”, a new industry that follows Robot and IT IndustryCYBERDYNE, Inc.13Cybernics Technology: Innovative core technology of Cybernics Industry*Cybernics: 
New academic field that fuses and combines cross-disciplinary fields. It is centered around humans, robots, and information systems, as well as other fields.Integrated Cybernics System : Fusion of “Human” + “Cyber/Physical Space”Realization of physical and informational interaction with ‘people’ to solve various issues in a super-aging society Create a “Cybernics Industry” for people and society, focusing on medical care, welfare, daily life, workplace, and productionMedicineCybernics TreatmentVital Sensinglong-term carePromoting 
IndependenceCare 
SupportLabor 
SupportWorkplaceTransportationIntegrated 
Cybernics SystemProductionCYBERDYNE Inc.Watch-over
for safetyMobility
SupportDaily lifeCleaning/
sterilization15Main business modelFor professional(B to B)For individuals(B to C)CYBERDYNECYBERDYNE Inc.*1 Includes revenue from sales and maintenances *2 Includes revenue from rental16Rental*1Service*2C-Startup : Innovation ecosystem to create Cybernics Industry2020/12 listedC-StartupCYBERDYNEMedical institutions, 
care facilities, companies, 
allied partnersUniversity, research institute, government
WEF Centre for 4th Industrial Revolution,
Consortium of cutting-edge medicine in the 21st centurySmart city council etc,.2022.03.31 updatedTechnical advicesFinancial supportBusiness supportIoH/IoTAIMed TechBigDataRoboticsCutting-edgetechnologyUniversity andresearch institutionsStart-ups and entrepreneursCEJ Fund (scale of 10 billion)Cybernics Industrybio/drug discoveryregenerative medicineCybernics Medical Innovation Base (A Building)Creation of new treatment with Cybernics Treatment combined with regenerative medicine and drug discoveryKingsky Front Tonomachi, KawasakiNew base with a view to global expansion 
(Directly connected to Haneda Airport)Tamagawa Sky Bridge
Tokyo International Airport (Haneda Airport)Cybernics Medical Innovation Base Building A2022/3　Main building
 completed2023/1　Start operationFeature ▶ Total floor space : 7,855m2
▶ All floors are designed as wet lab
▶ Animal Laboratory/ RI Laboratory/ 
 CPC Laboratory
▶ Genetic Recombination Experiments : P2
▶ Bio Hazaard LevelCYBERDYNE株式会社18【Medical】Cybernics TreatmentCYBERDYNE, Inc.19【Medical】Cybernics Treatment (functional improvement/rehabilitation treatment)Cybernics Treatment: Innovative method utilizing HAL for treating brain-nerve-musculoskeletal disordersHAL Lumbar TypeHAL Single Joint TypeHAL Lower Limb TypeCYBERDYNE, Inc.20【Neuromuscular disease】Outline and result of performance testPerformance test suggests high efficacy and safetyEfficacySafetyAmbulatory function remained above 
level at the beginning of the treatment over long durationReduced damage to the muscle tissueDistance covered in 2 min walk(Rate of change from the level before HAL Treatment)CK Blood Level*
(Rate of change from the level before HAL Treatment)*Test to identify damage to the muscleImprove 43%Before 
HAL Treatment
(=1)Improve 25%Improve 30%Before 
HAL Treatment
(=1)After 
13 monthsAfter 
25 monthsAfter 
37 monthsAfter 
7 monthsAfter 
19 monthsAfter 
31 months*Due to its progressive nature, typically ambulatory function will decline over time*Conventional exercise therapy will accelerate the damage on the muscle tissueCYBERDYNE, Inc.21Target disease: Spinal muscular atrophy, spinal and bulbar muscular atrophy, amyotrophic lateral sclerosis, 
Charcot-Marie-Tooth disease, distal muscular dystrophy, inclusion body myositis, congenital myopathy, muscular dystrophyReduced 21%Reduced 28%Reduced 34%Sample of decline of function over timeRevision plan for the insurance reimbursement pricing (from April 1, 2022.)High safety and efficacy was confirmed in 5 years of post-marketing surveillanceExcerpts from the Proposal to Evaluate the Medical Technology (why it should be reevaluated) submitted by the Japanese Society of Neurological Therapeutics – Translated by CYBERDYNE“During 5 years of post-marketing surveillance, the medical technology produced significant improvement of physical function towards slowly progressive neuromuscular disease, which are intractable diseases with no established treatment methods that are effective. The medical effect observed was unheard of by any existing treatment methods, including pharmaceuticals approved for these diseases. Due to the progressive nature of these intractable diseases, research on the natural course of the disease suggest a gradual decline of motor functions. However, when this medical technology was utilized repeatedly over a long duration of 3.5 years, an opposite trend was suggested, and motor function was maintained/improved. Furthermore, the medical technology did not increase the destruction of the patient’s muscles. The CK value in the blood** was actually in the declining trend, which is medically noteworthy. Thus, it was suggested that medical technology is a safe treatment method for progressive neuromuscular patients. The medical technology should no longer be regarded as a treatment method to support gait exercises. It should be reevaluated as a new treatment method to activate the loop of the patient’s brain-nerve systems.”CYBERDYNE, Inc.22Revision plan for the insurance reimbursement pricing (from April 1, 2022)To be excluded from Diagnosis Procedure Combination*J118-4 Ambulatory exercise treatment (with Robot Suit)Current
（FY2018-2021）OutpatientInpatientDPC hospital (80%)Separately calculatedCombined into other feesNon-DPC Hospital (20%)Separately calculatedSeparately calculatedAfter the revision
(From FY2022）OutpatientInpatientDPC hospital (80%)Separately calculatedSeparately calculatedNon-DPC Hospital (20%)Separately calculatedSeparately calculatedCYBERDYNE, Inc.23Revision plan for the insurance reimbursement pricing (from April 1, 2022)Increase of insurance reimbursement pricing (40,000 JPY per session)J118-4 Ambulatory exercise treatment (with Robot Suit)Current
（FY2018-2021）After revision
(FY20221) Basic fee900 points1,100 points2) Intractable diseases fee 
 addition900 points900 points3) Initial addition fee2,000 points2,000 pointsTotal pricing3,800 points/ sesion4,000 points/ sessionCYBERDYNE, Inc.24Establishing Cybernics Treatment as standard Treatment
 (Neuromuscular Disease)Information added on the Intractable Disease Information Center HPName of intractable diseasesIntractable Disease Information CenterIntractable Disease Information CenterAssociated Medical Society(For general users)(Summary, diagnostic criteria, etc.)(Guideline)Intractable Disease No.123Spinal and Bulbar Muscular AtrophyDescription addedAmyotrophic Lateral SclerosisDescription addedSpinal Muscular AtrophyDescription added10Charcot-Marie-Tooth DiseaseDescription added15Inclusion Body MyositisDescription added30Distal Muscular DystrophyDescription added111 Congenital Myopathy(Considering)113 Muscular DystrophyDescription addedGroup will continue to coordinate with associated medical societies targeting doctorsUnder the support and guidance of the Ministry of Health, Labor and Welfare, the Intractable Disease Information Center provides patients with intractable diseases, their families, and medical professionals with information necessary for their medical care and treatment on its website https://www.nanbyou.or.jpCYBERDYNE, Inc.25Target diseases: Spinal Cord InjuryDoubled walking speed for chronic patient (avg 7 years after injury)・10m walking speed : Doubled in HAL group and achieved p<0.001 ・6 min walking distance : x1.5 times in HAL group and achieved p<0.001It was cleared by the U.S. FDA as a medical device in 2017.
Additional data submitted by the company suggests that physical function is maintained even when the frequency of treatment is reduced after the intervention period.The U.S. FDA also approved the long-term therapeutic effect.10m walking speedParticipants：55 chronic spinal cord injury patient (meantime since injury 6.85 years) Method : Comparing speed of walking of these patients before and after 
 60 sessions (approx. 3 months) of HAL TreatmentResults : Time required to complete 10m walk improved from 
 70.45 seconds ±61.50 seconds to 35.22 seconds ±30.80 seconds　　　　(Patients doubled their average walking speeds after treatment with HAL)CYBERDYNE, Inc.Difference between groupp<0.001Avg 0.14m/secAvg 0.28m/secBefore treatmentAfter treatment26Target diseases: StrokeSignificant difference was observed for comparison of 6 min walking distance• 6 min walking distance (important secondary endpoint: recommended by PMDA) : superiority of HAL group was suggested. 
The dispersion is less likely to influence the result and it achieved p<0.022• 10m walking speed (primary endpoint): Result suggest greater improvement of HAL Group, but due to the number of cases, effect of dispersion remained and the result did to achieve p<0.05As a result of the analysis based on the data of 49 patients, excluding 3 patients who had major accidents in their daily life during the trial period, the amount of change was larger in the HAL group than in the control group, and the difference was statistically significant.The opinion of the study coordinator that the 6-minute walking distance is an appropriate assessment"Although walking speed improves in both compensatory and physiological walking, distance measured tends to increase in physiological walking but not in compensatory walking. As HAL is thought to remover physiological walking, evaluation of walking distance could have been more suited for this trial. It was reasonable that the 6-minute walking distance showed good results.”6 min walking distanceTarget patient : 49** acute stage stroke patient who have reached “plateau” state of improvement Method : Patient was separated into control group and HAL 
 treatment group and result was compared after 20-25 
 session without wearing HALResult : Average improvement of walking distance before and 
 after the intervention was　　　　　Control group : 17.34 ± 4.68 m
　　　　　HAL Treatment group: 34.10 ± 5.23 mDifference between group
p=0.022Average improvement
17.34 mAverage improvement
34.1 mControl group : 80 min conventional rehabHAL Treatment : 60 min conventional rehab + 20 min HAL TreatmentCYBERDYNE, Inc.Control group
(conventional rehab)HAL Treatment27Status of medical device application for strokeThe clinical significance and statistical significance of the primary endpoints, which are considered the most important evaluation points of the clinical trial results, are being discussed with the authorities with the study coordinating physicians and statistical experts.Point (1) Clinical significance In this clinical trial, the HAL Group consistently showed greater improvement than the control group in all endpoints, etc. Therefore, if HAL therapy is applied to stroke hemiplegia patients whose recovery is stalled by conventional rehabilitation, clinically and statistically effective improvement can be expected.Point (2) statistical significance of the primary endpoints In this trial, the p-value did not reach 0.05 due to the effect of variance and other factors in the analysis results of the primary endpoint of 10m maximum walking speed, but the efficacy of HAL treatment should be considered based on the overall effect of clinically meaningful improvement (*).❖The ASA (American Statistical Association) statement also states the principle that "scientific conclusions and business and policy decisions should not be based solely on whether a p-value exceeds a certain value (significance level)."CYBERDYNE, Inc.28Development pipelineTarget diseaseProduct DevelopmentClinical Trial
(Exploratory)Clinical Trial
(Validation)Application/examinationApproval
(public health insurance in Japan)Marketing
(Post-marketing
surveillance)Public health insuranceNeuromuscular Disease(8 types of disease 
such as ALS)Spastic paraplegia(HAM etc.)Spinal Cord InjuryStrokeCerebral PalsyMultiple SclerosisParkinsons’ DiseaseCYBERDYNE, Inc.Public
Health InsuranceStatusRevision of insurance schemePlanning for public health insurance (Germany, England)Planning for public health insuranceReview in processPreparing application for expansionPreparing application for expansionGermanPublic workersCompensation insuranceConsidering clinical trialPreparing trial for public health insurance (Germany)Planning for public health insuranceDiscussing with the authoritiesPlanning for public health insurancePlanning for public health insuranceInvestigator-initiated clinical trialConducting pilot researchConducting pilot researchThe above situation encompasses HAL products (Lower Limb Type and Lumbar Type). The Single Joint Type has already obtained medical device approval in Japan and the U.S. without limitation on target diseases.29Status of approvals by diseases and countries承認Significant progress in medical devices in the U.S., Europe, and Asia【HAL for Medical Use Lower Limb Type】As of March 31, 2022EMEASaudi ArabiaJapanUSAEUTurkeyMalaysiaIndonesiaThailandTaiwanSingaporeAustraliaStrokeSpinal Cord Injury Neuromuscular disease*Planning submission of application for medical device approvalPlanning clinical trialApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedApprovedAPAC(application in progress)(application in progress)CYBERDYNE, Inc.*Spinal muscular atrophy, spinal and bulbar muscular atrophy, amyotrophic lateral sclerosis, 
Charcot-Marie-Tooth disease, distal muscular dystrophy, inclusion body myositis, congenital myopathy, muscular dystrophy30Progress in US, EU and APAC despite COVIDHALを使用したNeuro HALFIT®を全国展開（全16箇所）Yellow indicates new introduction areas after After the outbreak of COVID-19New installation after April 2021Oversea expansion of HALGermany*Covered by Public workers compensation insurance and private insuranceEngland
Major contract with Hampshire County CouncilFrance
Hospices Civils de LyonPolandConstance care
*private insurance coverageItalyCentro San GirolamoSerbia Poliklinika Orto MDSaudi Arabia 　ALJ HospitalKuwaitThailand Piyavate HospitalMalaysia
SOCSO Rehab Center
Operated in 9 facilitiesSpain
BioCruces BizkaiaSwitzerlandTurkeyIndia IBS HospitalTaiwan CHC Group HospitalSeattle, WashingtonSNI Swedish Medical CenterJacksonville, FloridaBrooks Cybernics Treatment CenterPhillipines
4 facilities in Metropolitan AreaSingapore General HospitalCalifornia
RISE Physical Therapy (19 facilities)CYBERDYNE, Inc.Indonesia
Dr. Cipto Mangunkusumo National Central Public HospitalAustraliaEstablished RoboFitBrazil31【Healthcare】Neuro HALFITCYBERDYNE, Inc.32【Healthcare】Neuro HALFIT (functional improvement program)Program to improve brain-nerve-musculoskeltal function at Robocare CenterHAL Lumbar TypeHAL Single Joint TypeHAL Lower Limb TypeCYBERDYNE, Inc.33Neuro HALFIT at Home (for individuals in the life stage)Prevents the need for care by improving the function of the brain-nerve-muscular system through daily training at homeHAL is data-linked with the Cyberdyne Cloud, which visualizes biopotential signals that command body movements and posture information, etc. This system enables the wearer to obtain visual feedback and allows the trains to customize a program for each user based on the results of data analysis.CYBERDYNE, Inc.*Sales are classified as "service sales" in the case of home services provided by the Group, and "rental sales" in the case of product rentals based on rental contracts.Image of HAL MonitorAngle of the body trunk (front/back)Angle of the body trunk (left/right)Assist torqueBioelectrical signalsImage of useCamera viewTrial timeTorque setting3D model display 34HAL care prevention programSignificant improvement in mobility functions (daily activities such as standing, walking, running, sitting) of the elderlyInterim evaluation results of short-term intervention twice a week for a total of 10 sessions(Kanagawa Mirai Unwellness Cohort Study)Evaluation itemBefore HAL(Mean±SD)After HAL(Mean±SD)Improvement rateP-value10m walk (walking speed m/sec) 1.04±0.221.45±0.2539%<0.001***Locomotiv 5 check 
*Signs of motor unit deterioration 8.15±2.483.96±3.15105%<0.001***Subject n=74Average age : 74.8 ± 4.3 years oldCYBERDYNE, Inc.Research and development of nursing care prevention programs utilizing healthcare robots35Strategy for growth‣Growth scenario ‣Medical service ‣Prevention/early detection ‣WorkplaceCYBERDYNE, Inc.36Image of growth scenarioBusinessscaleInitiatives forGradual growthNowReinforcing existing business, pioneering new field
(evolution of the business model, M&A)Expanding existing business
(expanding usage, business towards individual users, etc.)Developing the business base
(Expanding product lineup, obtaining regulatory approvals in each countries)CYBERDYNE, Inc.Time37CYBERDYNE’s next step : Future of medical healthcare and healthy life Prevention/pre-symptomatic, medicine, rehabilitation/long-term careMedical/Healthcare/Healthy lifePre-Hospital
Early medical・life period Prevent/pre-symptomaticHospital
Diagnose, treat, inpatient/outpatientPost-Hospital Late medical・life period : rehab/long-term care early medical・life periodAcuteRecoveryLate medical・life periodHousehold・work place・life spaceHospitalHousehold・work place・life spaceClose coordination, fusion between medical and non-medical field to evolve into comprehensive initiativesCYBERDYNE, Inc.SquatSquatCybernics Medical Healthcare SystemPrevent, early detect and improve on daily basisCybernics Treatment and monitoring at hospitalsImprove independence to encourage continuous social activityHealth care monitoring in daily lifeSleep Apnea Syndrome, sleep deprivation checkCybernics Medical Healthcare System that prevent, early detect and improve on daily basis “Hospital”, “Facilities”, “Household”, “Workplaces"Cyberdyne Cloudwith innovative Cybernics SystemCloud ComputingActivity, sleeping checkHealthcare check and program to improve physical function at homeHealth Care Monitoring in the WorkplaceSeamless data linkage between hospitals, facilities, homes, and workplaces with IoH/IoTCYBERDYNE, Inc.39【Medical Healthcare Service for Individuals】 Neuro HALFIT at HomeExpansion of remote services connecting home and hospitals/facilities through cloud computingHouse（つーざー）(User)LTE/5G【Integrated Cybernics System】LTE/5GPhysical informationSupportInduce improvement of brain-nerve and physical function［Cloud］User authenticationDevice authenticationData basePhysical informationSupportInduce improvement of brain-nerve and physical functionHouse（つーざー）(User)Monitor tabletMonitor tabletCybernics DevicePhysical informationSupportRobocare Center（CYBERDYNE）Physical informationSupportRobocare Center（CYBERDYNE）Remote service to counter the pandemicPhysical informationPhysical informationSupportSupportFacility（つーざー）(professional)Monitor tabletMonitor tabletProfessionalStaffCYBERDYNE, Inc.40Cybernics DeviceExpansion of hubs in the medical healthcare service business for individuals Nationwide rollout of Neuro HALFIT to improve the neuromuscular systemHALを使用したNeuro HALFIT®を全国展開（全16箇所）Kobe Robocare2019/10
Eijyu CareNagoya Robocare2019/8Sapporo Robocare2019/8Rehab InnovationOkayama Robocare2019/5Ibara SeikiOsaka Robocare2018/10Eijyu CareHiroshima Robocare2019/7Sharem (Group of Araki Neurological Hospital) Kitakyushu Robocare2019/7Kokusai-gakuenFukuoka Robocare2020/9PRE FITOita RobocareShonan RobocareSuzuka RobocareKumamoto Robocare2020/11Kumamoto Kinoh Hospital41Sendai Robocare2019/5Vital NetTsukuba RobocareUrayasu Robocare2018/12
Japan Wheelchair Sports AssociationYotsuya Robocare (Tokyo)2019/10
Japan Wheelchair Sports AssociationPlanning to open 2~3 facilities in addition to existing 16CYBERDYNE, Inc.41Overseas expansion of medical service business for individuals (U.S.) Entering medical service business in the USName : RISE Healthcare Group Inc.*
*RISE Physical Therapy is acquired and established as a new business control company.Business : Outpatient physical therapy
No. of facilities : 19 medical centers　　　　 (Ranked third in San Diego)LA Metropolitan area
Population: 13 million
(2nd largest in US*)Both areas combined accounts for 5% in the entire US populationSan Diego area
Population: 3.3 million
(17th in US*)Based on San Diego, the group is expanding facilities to LA (2nd biggest metropolitan area in the U.S)42CYBERDYNE, Inc.* https://en.wikipedia.org/wiki/List_of_core-based_statistical_areasGrowth scenario of medical service business for individuals (U.S.) Formulating platform that could reach individuals directlyWorkplace
/living spaceDaily monitoring at 
work and everywhereHomeHealthcare check at home and functional recovery programMedical facilityCybernics treatment
/monitoringOrthopedic+brain-nerve diseases (target of HAL)Typically done manually by PT (can differentiate with HAL)Growing market due to aging population (Annually 33.1 billion=3.7 trillion yen)*Players are dispersed (potential for further growth through M&A)US PT 
marketPT：Physical TherapyRISE Healthcare Group Inc.→First facility in the west coast areaFunctional recovery at home and daily healthcare monitoring
Preparing for launch of service towards individuals (consider further M&A)CYBERDYNE, Inc.* “Physical Therapists in the US” IBIS World43Cyvis-Ultra small Vital SensorExpands remote service that connects households to hospitals and facilities【Integrated Cybernics System】［Cloud］User authenticationDevice authenticationData baseRemote service to counter the pandemicPhysical informationPhysical informationSupSupportportiPnhforysicmal ationPhysical informationSupportSupportEarly detection of risks of Cerebrovascular disease, heart disease, House（つーざー）(User)Facility（つーざー）(professional)Early detection of sleep apnea syndrome riskHouse（つーざー）(User)Mobile tabletCyvisMobile tabletCyvis (Option)Monitor tabletMonitor tabletCYBERDYNE, Inc.ProfessionalStaff44SupportLTE/5GHouse（つーざー）(User)Monitor tabletCybernics DeviceSupportPhysical informationInduce improvement of brain-nerve and physical functionHouse（つーざー）(User)Monitor tabletCybernics DevicePhysical informationInduce improvement of brain-nerve and physical functionLTE/5G【Prevention and early detection】Cerebrovascular, cardiac diseaseHealthcare monitoring on daily basis with Cyvis seriesContinuous measurement of wide range of vital data・Cardiac activity・brain activity・body temperature・SpO2・Body movements・Breathing (optional) Check for arrhythmia and atrial fibrillation to prevent myocardial infarction and cerebral infarction* Optional feature enables continuous monitoring of sleep respiratory status and screening for SAS (Sleep Apnea Syndrome)*Cyvis-1 medical device notification filed (April 2022), trial provision to users started (May 2022)CYBERDYNE, Inc.45【Prevention and early detection】Checks health statusEasy daily health checks (developer C2 became the company’s subsidiary) No. of download
3.2 millionSleep data75 millionActive user300 thousand 
per monthSleeping appRank 1in Japan"JUKUSUI”, a Sleeping support app that visualizes sleepCYBERDYNE, Inc.*Revenues from usage fees for smartphone applications are classified as "rental revenues.46【Prevention and early detection】 Sleep Apnea SyndromeIdentifies risks of Sleep Apnea Syndrome at early stagesSmartphone app “JUKUSUI”small vital sensor “Cyvis”Active user300 thousand 
per monthCheck sleeping conditionHigh-precision screening tests（Measures breathing during sleep）Easy and routine screening for health management of drivers, etc.CYBERDYNE, Inc.47【Workplace】HAL Lumbar Type for CarePromoting digital innovation in care with English government organizationHampshire County, England- Verification confirms effectiveness of HAL- With a budget of 500 million yen, a total of 127 units will be introduced- Suggested additional purchases of up to 
1.5 billion yenConfirmed effects- Reduced burden: less fatigue and tension- Reduced risk of injury- Positive feedback from caregivers- Increased caregiver efficiency: less need for two people to work (more tasks can be done by one person) CYBERDYNE, Inc.48Promotion video of Hampshire County councilhttps://www.youtube.com/watch?v=sF-XYdVF3MY【Workplace】HAL Lumbar Type (Labor Support)Visualizing the workload and physical condition of workersCybernics Integrated SystemConstruction sites, airports, and distribution warehouses etc. Active type and
light weight• Can be worn for long hoursCompact design
(back won’t be covered)• Can be used with safety belts (full-body type) 
and air conditioning suits!Assist walking• Can be moved smoothly on siteAble to move in mid-back position. • Respond with assistance in a variety of 
practical tasks!IoH/IoT device• Visualize workload analysis and operation status! 
Integrated production managementWearable Cyborg• It moves according to the wearer's intentionCan be worn in 10 sec• Easy to put on and take off, share with multiple people!Waterproof/dustproof 
(IEC reg, IP54)• Can be worn outdoors, even in the rain!Wearable Cyborg HALLabor managerLabor management and work efficiencyCYBERDYNE, Inc.49【Workplace】Disinfection/Cleaning Robot CL02Operationalizing next-generation technologies in a post-coronary societyExtensiveCleaning ability•High speed autonomous navigation (Can safely clean at 4km/h to cover massive space in short time• Massive cleaning area (Detects wall that is 30m away and cover max 3,000m2 with full charge battery)•High vacuum performance (one of the best in the industry)Can be used for multiple tasks such as disinfection••Disinfection agent sprayer (Disinfects handrails and benches)UV Ray Disinfector (set on the bottom of the robot to disinfect floors)Airports, office buildings, facilities, shopping centers etc.CYCLES Cloud & ServerCyberdyne Cloud&ServerVisualizes 
its workDust distribution map (visualizes result of the task)Navigated route (to create efficient and effective cleaning plan) Automatically rides on the elevatorElevator interface unit developed inhouse 
(Can connect to elevators developed by multiple vendors)Can work on multiple floors (Expands the space that can be cleaned)RobotsHumanInformation transfer and remote controlCloud linkage“CYCLES” designed for the Robot (realizes high usability and management)Integration with the base systemCYBERDYNE, Inc.50••••••SDGs for Society5.0/5.1CYBERDYNE, Inc.51Four projects that contributes to achieving SDGsMain initiativesMain initiativesMain initiativesMain initiativesHealth Risk Management with Cyberdyne CloudForm social infrastructure to create the Cybernics IndustryRealize Society 5.0/5.1, a future 
society that accelerates innovation• Develop Cyberdyne Cloud to accumulate, analyze, and perform AI processing of big data on people and things (IoH/IoT big data) obtained through all Cybernics Technologies equipped with communication functions• Realize personalized healthcare through Cyberdyne Cloudinformation daily• Develop sensing technology to monitor vital • Develop HAL at Home as a new service that can share user's information on their training sessions conducted at home using HAL with medical and care facilities• Establish a system to support companies and human resources that develop and deploy technologies and services that solve social problems• Construct Cybernics Innovation Base to promote innovation in the medical and biotechnology fields• Continue the projects at the Next-generation multi-purpose robotized production facility to induce innovation in the production field• Develop mobility technologies that are safe, affordable, and ready for use by all people• Develop a future city where all people, including the elderly and disabled, can easily access public spaces.• Establish educational institutions that develop knowledge and skills to help people.• Create shared spaces that promote innovation and scientific research and areas for field testingDevelop Cybernics Technology to support people with reduced physical function• Disseminate Cybernics Treatment that promotes functional improvement and regeneration of the brain, nervous system, and muscular system using a Wearable Cyborg HAL, as a global standard treatment• Disseminate Wearable Cyborg HAL to improve the level of care required by the elderly and prevent severe illness and prevent frailty and maintain independence as physical functions decline with age• Develop Cyin for Living Support for people with severe disabilities who cannot speak or write as they wish due to the progression of intractable diseases to communicate and operate machines without speech or physical movementCYBERDYNE, Inc.52Develop Cybernic Technology to support people with 
reduced physical functionOur contributionBy developing the Wearable Cyborg HAL for medical and welfare fields, and Cyin for Well-being to support severely disabled to communicate their intentions, we are supporting the elderly and disabled person by maintaining and improving their functions. We also help them express what they have in mind. 
 We also develop another type of HAL to support people engaged in heavy work.
 This project promotes the empowerment of these people and their social, economic, and political inclusion.Main target10.2 by 2030 empower andpromote the social, economic and political inclusion of all irrespective of age, sex, disability, race, ethnicity, origin, religion or economic or other statusCybernics Treatment Center and
Medical HALCyin for Living Support to support severely disabled person on their communicationHAL Lumbar Type to support 
various heavy workDisseminating Medical HAL as a global standard treatmentAs of the end of March 2021, HAL for Medical Use is available in 16 countries and regions, including Southeast Asia and South Asia, as a treatment technology for stroke, spinal cord injury, and intractable neuromuscular diseases.
　In addition, in order to contribute to solving the needs of developing countries, we have been selected by the Japan International Cooperation Agency (JICA) to conduct a research project in Brazil.
 We will continue to disseminate the technology. Post-discharge care at the Robocare CenterF o r t h o s e w h o w a n t t o k e e p improving their physical functions after they get discharged from the hospital, we offer Neuro HALFIT at self-funded rehabilitation facilities called RoboCare Center. As of the end of March 2021, they are 16 centers around Japan. A user can also access similar programs at self-funded rehabilitation facilities with w h i c h w e h a v e c o o p e r a t i v e relationships.
 In addition, we have formed alliances with private insurance companies such as Daido Life, AIG Insurance, and Sompo Japan to cover the cost of such programs for their policyholders.
 We will continue our efforts to improve physical and economic access.Improving the working environmentJob turnover due to the onset of back p a i n a n d t h e d e t e r i o r a t i o n o f performance caused by frequent heavy lifting is becoming a significant issue in nursing care, construction, and logistics.
 The Company develops HAL Lumbar Type to reduce the risk of developing back pain by reducing the load applied to the lower back. The t e c h n o l o g y e m p o w e r s p e o p l e engaged in heavy lifting and enables the worker to continue working longer and safer. 
 As of the end of September 2021, 1,575 units of HAL Lumbar Type were in operation.
 This product is currently available in Japan and the UK. We will continue to disseminate the technology to more countries and regions.Supporting communication for the severely disabledWe develop Cyin for Living Support, which enables people with severe disabilities who cannot speak or move their bodies due to the progression of intractable diseases to communicate and operate devices.
 The product is available on the market. Daido Life Insurance donated the product to several patient groups and patient support groups to promote this endeavor. 
 We will continue to work on additional functions and offer the product outside of Japan once it is ready.CYBERDYNE, Inc.53Health Risk Management with Cyberdyne CloudMain target3.dStrengthen the capacity of all countries, in particular developing countries, for early warning, risk reduction and management of national and global health risksOur contributionCybernics Technology deployed in various fields such as medicine, nursing-care, production, and other workplaces with households, integrally connects people's internal information (brain nerve information, physiological information, etc.), people's external information (behavioral information, lifestyle information, etc.), and environmental information with a supercomputer. 
 The Company works on the system that accumulates, analyzes, and AI processes all the IoH/IoT Big Data obtained through this process, contributing to personalized medicine, early warning of health risks, and enhancing risk mitigation and risk management capabilities.Cybernics Medical Healthcare System that prevent, early detect and improve on daily basis “Hospital”, “Facilities”, “Household”, “Workplaces"Cybernics Treatment and monitoring at hospitalsCybernics Cloudwith innovative Cybernics SystemHealth care monitoring in daily lifeCloud ComputingSleep Apnea Syndrome, sleep deprivation checkImprove independence to encourage continuous social activityActivity, sleeping checkHealthcare check and program to improve physical function at homeHealth Care Monitoring in the WorkplaceRelease of Cyberdyne CloudThe Company develops Cyberdyne Cloud to connect different fields and provide feedback on health risks based on IoH/IoT Big Data. In Japan, a system that allows users to send information on their training sessions from home to a facility and receive timely support from the facility is already in operation from November 2020.
 We will continue to expand this system to other fields according to the development of products and services. We will also offer the system outside Japan to contribute to health management in all countries, including developing countries.Realizing personalized healthcareBy accumulating, analyzing, and AI-processing IoH/IoT Big Data related to a single user across different fields, we will realize personalized healthcare that will maximize the effect and safety of that user.
　This initiative is being carried out simultaneously with the formation of IoH/IoT Big Data for all users. We will continue to expand this system to o t h e r fi e l d s a c c o r d i n g t h e d e v e l o p m e n t o f p r o d u c t s a n d services. We will also offer the system outside Japan to contribute to health management in all countries, including developing countries.t o Developing vital sensing technologyIn addition to developing the W e a r a b l e C y b o r g H A L a n d autonomous navigation technology, w e a r e d e v e l o p i n g s e n s i n g technology to prevent and detect diseases.
 For example, commercialization of Cyvis, an ultra small-sized vital sensor to detect arteriosclerosis and arrhythmia at an early stage, and a photoacoustic imaging device to enable real-time analysis of capillary information.
 By promoting these products, we will a c c u m u l a t e i m p o r t a n t v i t a l information that will lead to the prevention and early detection of diseases, thereby contributing to the enhancement of capabilities for health risk management.
　New service: HAL at HomeIn April 2020, we launched a new service, HAL at Home. This service can create exercise opportunities, which many people lost due to the voluntary restraint from going out because of COVID-19.
 The service became a new option for safe and effective training that the user can practice at home. HAL at Home also realized the visualization of exercise information and remote online support by professional staff through H A L ' s b u i l t - i n c o m m u n i c a t i o n functions.
 At the end of September 2021, HAL a t H o m e h a v e r e a c h e d a n accumulation of 369 contractsCYBERDYNE, Inc.54Form social infrastructure to create the Cybernic IndustryMain target9.2Promote inclusive and sustainable industrialization and, by 2030, significantly raise industry’s share of e m p l o y m e n t a n d g r o s s domestic product, in line with national circumstances, and double its share in least developed countriesOur contributionWe are working to create an inclusive and sustainable industry called Cybernics Industry by building an innovation ecosystem called C-Startup and facilities to accelerate innovation in medicine/biotechnology and production.C-Startup, the foundation for the creation of new industriesC-Startup is an innovation ecosystem to create a new industry for solving problems of people and society: Cybernics Industry. We work together with startups and entrepreneurs with similar visions, regardless of their nationalities. 
 We accelerate creating the Cybernics Industry by providing technical advice by Yoshiyuki Sankai (CEO of CYBERDYNE/Professor of Tsukuba University) and financial support by CYBERDYNE and its related Fund.
　As part of this initiative, we have formed partnerships with a total of 21 startups and are managing a 10 billion yen fund to support this endeavor.Promoting the vision of the Cybernics IndustryThe Company promotes the vision of the Cybernics Industry, a new industry that fuses Human and Cyber/Physical Space, both domestically and internationally. With this initiative, we are leading the efforts to form Cybernics Industry together with industry, academia, and government.
　For example, in 2019, we communicated this vision to various countries at the G20 Trade and Digital Economic Ministerial Meeting held in Tsukuba City, Ibaraki Prefecture.
　We will continue to share our vision of the Cybernics Industry as a foundation for industrial and technological innovation.C-Startup2020/12 listedCYBERDYNEMedical institutions, 
care facilities, companies, 
allied partnersUniversity, research institute, government
WEF Centre for 4th Industrial Revolution,
Consortium of cutting-edge medicine in the 21st centurySmart city council etc,.552021.9.21 updatedExterior imageActivities at the Next-Generation Multipurpose Robotic Manufacturing BaseIn Koriyama City, Fukushima Prefecture, we have constructed a next-generation production base to produce robots and devices with Cybernics Technology. In this facility, the Company embedded the skills of experienced workers into the robots so the robots and human workers can work in harmony.
 The Company constructed the facility in 2016 and completed a registration to manufacture medical devices in 2020. G20 delegates visit CYBERDYNE HQ (2019)Construction of Cybernics Medical Innovation BaseWe plan to construct the Cybernics Innovation Base in Kawasaki City, Kanagawa Prefecture, as a facility to accelerate innovation in the medical and biotechnology fields. The facility will house a cluster of medical and biotechnology ventures. The Company, universities, and resident companies can conduct a clinical trial in the facility on their own and through collaboration.
　The facility will be constructed adjacent to Haneda International Airport in February 2022. CYBERDYNE, Inc.Exterior of the facility55Technical advicesFinancial supportBusiness supportIoH/IoTAIMed TechBigDataRoboticsCutting-edgetechnologyUniverStart-CEJ Fund (scale of 10 billion)Cybernics Industrybio/drug discoveryregenerative medicineRealize Society 5.0/5.1, a future society that accelerates innovationOur contributionUsing innovative Cybernics Technology, we promote the fusion of Human and Cyber/Physical Space to create Society 5.0/5.1. We envision this future society as a techno-peer-supported society where technology and human support each other as partners.Creation of Society 5.0/5.1Society 5.0 is a concept first proposed in Japan's Fifth Science and Technology Basic Plan as the ideal future society. In this society, science and technology connect all people and things, sharing various knowledge and information to create new values never seen before.
 We contribute to the creation of Society 5.0 by implementing Cybernics Technology in the various business fields to integrate internal information (brain nerve information, physiological information, etc.), people's external information (behavioral information, lifestyle information, etc.), and environmental information with a supercomputer. As one of the leaders in this challenge, we work to explore the society beyond Society 5.0/5.1.Mobility InfrastructureFuturistic housingWe are working on personal mobility and drones for transportation that is safe, inexpensive, and easy to use, taking into consideration the needs of the elderly and disabled living in the community.
　We are also planning cities based on the premise of introducing mobility, which will shorten travel time and create new connections and added value between functions and facilities.
 W h i l e d e v e l o p i n g m o b i l i t y infrastructure in-house, we are also collaborating with startups that are developing related technologies.Shared EconomyWe plan to shift from the conventional model of occupying information, people, goods, space, and time to a new form of a city where we can share and help each other.
　We will work to achieve success with the allies formed in C-Startup. We will also continue to gather people and companies with seeds related to Cybernics and accelerate the creation of innovation through sharing and mutual aid of information, people, goods, space, and time.Through daily health management and lifestyle support infrastructure based on Cybernics Technology, we will develop housing where all people, including the elderly and disabled, can live in harmony with technology and mutually support each other to ensure peace of mind. 
 Specifically, various Cybernics Technologies, such as the Wearable Cyborg HAL, autonomous navigation robots, and vital sensors, will be i n t o e v e r y s p a c e , i n t r o d u c e d including residences. Personal health information will be accumulated, analyzed, and processed by AI to be linked to medical facilities to manage each person's health and safety better. An educational institution that nurtures the next generation of human resourcesThrough collaboration between industry, academia, and government, we are planning an educational institution to foster the next generation of innovators.
　We will nurture the next generation of innovators with educational institutions ranging from graduate school to elementary school, taught by instructors from various companies.Main target11.2by 2030, provideaccess to safe, affordable, accessible and sustainable transport systems for all, i m p r o v i n g r o a d s a f e t y, notably by expanding public t r a n s p o r t , w i t h s p e c i a l attention to the needs of i n v u l n e r a b l e t h o s e situations, women, children, persons with disabilities and older persons11.7by 2030, provideuniversal access to safe, inclusive and accessible, green and public spaces, particularly for women and children, older persons and persons with disabilitiesCYBERDYNE, Inc.56perspective drawing of the future cityOther initiatives to achieve SDGsCYBERDYNE, Inc.57We contribute to the achievement of other sustainable development goals set by the United Nations through various initiativesWe are developing a robot that automatically collects fruits and vegetables at the optimal harvest time using a camera to determine the sugar content.We communicate with public and private insurers to get programs with HAL covered by insurance to make the program more affordable and accessible to people with disabilities.Takezono High School in Tsukuba City featured our company's challenge in their SDGs Karuta, a card game where players can learn about SDGs while having fun.To create a comfortable working environment for workers of all genders, we grant flexible work styles. 
 For example, both male and female workers in our company have a record of taking childcare leave.By developing a toilet docking robot that assists the elderly and other people to use the toilet, we are working to help the elderly become more independent and reduce the burden of nursing care.We are working on the development of environmentally friendly, next-generation mobility technologies.Other initiatives to achieve SDGsCYBERDYNE, Inc.58We contribute to the achievement of other sustainable development goals set by the United Nations through various initiativesWe help people with disabilities return to life and work by improving their physical functions.In cooperation with various organizations, we thoroughly manufacture products following international safety standards, and we produce products that users can use safely.To support recovery from natural disasters, we are lending HAL Lumbar Type, which reduces the load on the lower back, to disaster areas free of charge.Based on the motto "science exists for humans and society," we implement various measures to prevent our technology from being diverted to weapons. We are working to solve social issues and realize a peaceful world through our business.We actively collaborate with industry, government, academia, and other business fields to pioneer the future together.This presentation contains forward-looking statements concerning CYBERDYNE, Inc. and its Group’s future plans, strategies and performance. Forward-looking statements contained in this presentation are based on information currently available and on certain assumption redeemed rational at the time of creation of this presentation. As such, due to various risks and uncertainties, the statements and assumption does not guarantee future performance, may be considered differently from alternative perspectives and may differ from the actual result.Further, this presentation contains statements and information regarding corporate entities other than those belonging to the CYBERDYNE group, which have been complied from various publicly- available sources. CYBERDYNE does not verify nor guarantees accuracy and appropriateness of those information.CYBERDYNE, Inc.59