第一三共（4568） – Notice Regarding a Change of Major Shareholder

Company name: DAIICHI SANKYO COMPANY, LIMITED Representative: Sunao Manabe, Representative Director, President and CEO (Code no.: 4568, First Section, Tokyo Stock Exchange) Please address inquiries to Junichi Onuma, Vice President, Corporate Communications Department Telephone: +81-3-6225-1126 https://www.daiichisankyo.com Notice Regarding a Change of Major Shareholder Tokyo, Japan (March 23, 2022) – Daiichi Sankyo Company, Limited (hereafter, the Company) hereby informs that a major shareholder of the Company has changed on March 15, 2022 as below. 1. Background of the Change The Company has confirmed the change of holding shares of a major shareholder based on the Large Shareholding Report (Change Report) submitted by the shareholder below to the Director-General of the Kanto Local Finance Bureau on March 23, 2022. 2. Outline of the Shareholder (1) Name (2) Location Capital Research and Management Company 333 South Hope Street, Los Angeles, CA 90071, U.S.A. (3) Name and title of representative Donald H, Rolfe, Secretary (4) Business domain Investment management business 3. Number of Voting Rights (Holding Shares) and Percentage of Voting Rights of the Shareholder Number of voting rights Percentage of Ranking of (Number of holding shares) voting rights major Before change 1,942,356 (as of February 4, 2022) (194,235,678 shares) After change 1,715,503 (as of March 15, 2022) (171,550,355 shares) 10.13% 8.95% shareholders ― ― 1 Note 1: The above is written on the basis of the Large Shareholding Report (Change Report) submitted by the shareholder in question. It does not represent a confirmation by the Company of the actual number of shares held in the name of the shareholder in question. The ranking of major shareholders has not been confirmed, and therefore is not indicated here. Note 2: The percentage of voting rights of all shareholders as of February 4, 2022 was calculated on the basis of a total number of voting rights of all shareholders of 19,159,048, which is based on the total number of issued shares as of February 4, 2022 (1,947,034,029) minus the number of treasury shares held by the Company (30,308,841) as of February 4, 2022. The percentage of voting rights of all shareholders as of March 15, 2022 was calculated on the basis of a total number of voting rights of all shareholders of 19,159,048, which is based on the total number of issued shares as of March 15, 2022 (1,947,034,029) minus the number of treasury shares held by the Company (30,308,841) as of March 15, 2022. Note 3: The percentage of voting rights of all shareholders is rounded to the second decimal place. 4．Future Outlook There is nothing special to describe regarding future outlook. 2